Instructive biomaterials for regenerative medicine
Feel like a real scientist by building bioactive scaffolds using the methods and techniques that are used by researchers working in tissue and organ regeneration. Test your scaffold’s ability to induce angiogenesis, a crucial property for the successful regeneration of tissues, and for the organ replacement of the future.
Regenerative medicine deals with replacement or regeneration of human cells, tissues or organs, to restore or establish their normal function. Among the strategies in regenerative medicine, in situ tissue regeneration uses the body’s own regenerating capacity by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the site of the injury. This approach relies on the development of target-specific biomaterial scaffolds that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues. An appropriate microenvironment provided by implanted scaffolds would facilitate recruitment of host cells that can be guided to regenerate structural and functional tissues. The chemistry, architecture, porosity and rate of degradation of the scaffolds all contribute to an appropriate mechanical environment and facilitate cell attachment, proliferation and migration, waste-nutrient exchange, vascularization and tissue in-growth. To meet these requirements, modern scaffold fabrication methods are applied, enabling architectural designs with defined macro-, micro- and nanostructure. Participants will review these fabrication methods and will test the capability of these scaffolds to induce angiogenesis, a crucial property for the successful regeneration of tissues.
Biology, biochemistry, biotechnology, bioengineering
Lab coat, laptop and digital photo camera (smartphone camera)