• IBEC
  • IBEC
  • IBEC

Instructive biomaterials for regenerative medicine

The Project

Feel like a real scientist by building bioactive scaffolds using the methods and techniques that are used by researchers working in tissue and organ regeneration. Test your scaffold’s ability to induce angiogenesis, a crucial property for the successful regeneration of tissues, and for the organ replacement of the future.

Regenerative medicine deals with replacement or regeneration of human cells, tissues or organs, to restore or establish their normal function. Among the strategies in regenerative medicine, in situ tissue regeneration uses the body’s own regenerating capacity by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the site of the injury. This approach relies on the development of target-specific biomaterial scaffolds that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues. An appropriate microenvironment provided by implanted scaffolds would facilitate recruitment of host cells that can be guided to regenerate structural and functional tissues. The chemistry, architecture, porosity and rate of degradation of the scaffolds all contribute to an appropriate mechanical environment and facilitate cell attachment, proliferation and migration, waste-nutrient exchange, vascularization and tissue in-growth. To meet these requirements, modern scaffold fabrication methods are applied, enabling architectural designs with defined macro-, micro- and nanostructure. Participants will review these fabrication methods and will test the capability of these scaffolds to induce angiogenesis, a crucial property for the successful regeneration of tissues.

Matching profiles

Biology, biochemistry, biotechnology, bioengineering

Required materials

Lab coat, laptop and digital photo camera (smartphone camera)

Coordinator of the project
Soledad Pérez

Soledad Pérez

Soledad Pérez began her research career in 1998 when she was awarded a scholarship by the European Community under the Latin America Academic Formation program to work as a postgraduate fellow at the department of Clinical Biochemistry at St. Bartholomew’s and the Royal London School of Medicine and Biochemistry at Queen Mary and Westfield College in London. Upon completion of her postgraduate fellowship, she started her doctoral research at the department of Oral Cell Biology, Academic Centre of Dentistry (ACTA) in Amsterdam. In 2006 she worked as a postdoctoral researcher at the department of Oral Cell Biology at the Free University in Amsterdam. After this, she worked as a postdoctoral fellow in the department of Tissue Regeneration at the University of Twente in The Netherlands. In 2007 she joined the departments of Plastic and Reconstructive Surgery and Otorhinolaryngology at Erasmus Medical Centre in Rotterdam as a postdoctoral research fellow. Finally, in 2012 she joined the Biomaterials for Regenerative Therapies Group at IBEC. Her research interests include the design of scaffolds and their interaction with cells in in vitro as well as in vivo settings.

Associated researchers
Jesús Ordoño

Jesús Ordoño

Jesús Ordoño studied a bachelor degree in Biotechnology at the University of Barcelona (UB), where he graduated with best academic expedient honors. He obtained an Erasmus grant to study at the Université Libre de Bruxelles in Belgium, where he worked on his final bachelor thesis about developmental genetics at the Institut des Biomolécules Max Mousseron (IBMM). Then he did a master’s degree on Nanoscience and Nanotechnology at the UB, during which he was awarded with a Master of Excellence grant and started to work at IBEC on the angiogenic effect of calcium and copper nanoparticles. In 2015, he started his PhD on lactate-releasing materials for cardiac regeneration in the Biomaterials for Regenerative Therapies group at IBEC.

The center
IBEC

The Institute for Bioengineering of Catalonia (IBEC) is a research center which carries out excellent interdisciplinary research at the highest international level which, by creating knowledge, helps to improve health and quality of life and generate wealth.